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ACNE FULMINANS

Introduction Acne fulminans is the most severe form of acne and is characterized by the abrupt development of nodular and suppurative acne lesions in association with systemic manifestations. This uncommon variant primarily affects boys 13–16 years of age. Clinical presentation Patients typically have mild to moderate acne prior to the onset of acne fulminans, whenContinue reading “ACNE FULMINANS”

TISSUE AND ORGAN-SPECIFIC CONTRIBUTION TO INSULIN RESISTANCE

MUSCLE The skeletal muscle plays an important role for glucose uptake. Approximately 80% of the glucose is transported into the skeletal muscle in an insulin-dependent manner. In this respect, the skeletal muscle is an important organ involved in the development of insulin resistance. Ectopic fat deposition seems also to be highly important for the developmentContinue reading “TISSUE AND ORGAN-SPECIFIC CONTRIBUTION TO INSULIN RESISTANCE”

THE ROLE OF THE ADIPOCYTE AND OBESITY IN TYPE 2 DIABETES

INTRODUCTION Obesity is one of the most important predisposing factors for the development of insulin resistance and type 2 diabetes. Patients with an increased visceral (mesenteric and omental) fat mass, as well as persons with increased liver fat mass, have an increased risk for insulin resistance and type 2 diabetes. This explains why measuring the waistContinue reading “THE ROLE OF THE ADIPOCYTE AND OBESITY IN TYPE 2 DIABETES”

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